ABSTRACT
Sarcoidosis is a disease characterized by noncaseating granulomas that can affect many tissues and organs, especially the lungs. In sarcoidosis, osteopenia, osteoporosis and pathological bone fractures can be seen with the direct effect of granulomas, osteoclast activating factors such as 1.25-dihydroxyvitamin D released from macrophages, and the use of glucocorticoids. Bone involvement of sarcoidosis produces typical cystic structures in the hands and feet. Vertebral involvement is rare and may cause lytic, sclerotic or mixed lesions. It should be differentially diagnosed from metastatic lesions.
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