ABSTRACT
Acne vulgaris is a disorder that affects the pilosebaceous follicles on the skin. Isotretinoin is used in the treatment of severe acne and it may have side effects such as arthritis, myalgia, hyperostosis, sacroiliitis in the musculoskeletal system. Rarely seen sacroiliitis is usually recovered by discontinuation of isotretinoin. In this article, it was presented that a 19-year-old patient with bilateral and widespread sacroiliitis as a result of isotretionin use. Despite the use of non-steroidal anti-inflammatory drugs, sacroiliitis, which did not regress, responded dramatically to methyl prednisolone treatment.
Keywords:
Acne vulgaris, isotretinoin, methyl prednisolon, sacroiliitis
References
1
Solmaz D, Akar S, Soysal O, Akkoc Y, Can G, Gerdan V, et al. Performance of different criteria sets for inflammatory back pain in patients with axial spondyloarthritis with and without radiographic sacroiliitis. Clin Rheumatol 2014;33:1475–9.
2
Vallerand IA, Lewinson RT, Farris MS, Sibley CD, Ramien ML, Bulloch AGM, et al. Efficacy and adverse events of oral isotretinoin for acne: a systematic review. Br J Dermatol 2018;178:76-85.
3
Brelsford M, Beute TC. Preventing and managing the side effects of isotretinoin. Semin Cutan Med Surg 2008;27:197-206.
4
Levinson M, Gibson A, Stephenson G Sacroiliitis secondary to isotretinoin. Australas J Dermatol 2012;53:298-300.
5
Rozin AP, Kagna O, Shiller Y. Sacroiliitis and severe disability due to isotretinoin therapy. Rheumatol Int 2010;30:985-6.
6
Barbareschi M, Paresce E, Chiaratti A, Ferla Lodigiani A, Clerici G, Greppi F. Unilateral sacroiliitis associated with systemic isotretinoin treatment. Int J Dermatol 2010;49:331-3.
7
Eksioglu E, Oztekin F, Unlu E, Cakci A, Keyik B, Karadavut IK. Sacroiliitis and polyneuropathy during isotretinoin treatment. Clin Exp Dermatol 2008;33:122-4.
8
Priest JR, Low D, Wang C, Bush T. Brucellosis and Sacroiliitis: A common presentation of an uncommon pathogen. J Am Board Fam Med 2008;21:158–61.
9
Papagelopoulos PJ, Papadopoulos EC, Mayrogenis AF, Themistocleous GS, Korres DS, Soucacos PN. Tuberculous sacroiliitis. A case report and review of literature. Eur Spine J 2005;14:683–8.
10
Hermet M, Emeline M, Flipo RM, Dubost JJ, Allanore Y, Ziza JM, et al. Infectious sacroiliitis: a retrospective multicentre study of 39 adults. BMC Infect Dis 2012;12:305.
11
Lehucher-Ceyrac D, Weber-Buisset MJ. Isotretinoin and acne in practice: a prospective analysis of 188 cases over 9 years. Dermatology 1993;186:123.
12
Amichai B, Shemer A, Grunwald MH. Low-dose isotretinoin in the treatment of acne vulgaris. J Am Acad Dermatol 2006;54:644.
13
Geller AS, Alagia RF. Sacroiliitis after use of oral isotretinoin--association with acne fulminans or adverse effect? An Bras Dermatol 2013;88(6 Suppl 1):193-6.
14
Alkan S, Kayiran N, Zengin O, Kalem A, Kimyon G, Kilinc EO, et al. Isotretinoin-induced Spondyloarthropathy-related Symptoms: A Prospective Study. J Rheumatol 2015;42:2106-9.
15
Baykal Selçuk L, Aksu Arıca D, Baykal Şahin H, Yaylı S, Bahadır S. The prevalence of sacroiliitis in patients with acne vulgaris using isotretinoin. Cutan Ocul Toxicol 2017;36:176-9.
16
Yılmazer B, Coşan F, Cefle A. Bilateral acute sacroiliitis due to isotretinoin therapy: a case report. Int J Rheum Dis 2013;16:604-5.
