Fibromyalgia is a chronic musculoskeletal disease, characterized by tender points in various areas at body and widespread pain musculoskeletal system and unknown etiology, in which metabolic, immunologic and neuroendocrin abnormalities are seen. In this study, 45 female patients were enrolled according to 1990 ACR fibromyalgia criteria. They were divided to 3 groups, with 15 patients; normal, preobese and obese, depending to the body mass index. They were tested for bone mineral density of the lomber spine and femur, using dual energy x-ray absorptionmeter. The depression presence was investigated by Hamilton Depression Scale. The bone mineral density of L1-4 region of fibromyalgic normal body weight patients were normal range and there was no significant statistical difference between others groups. In contrast, femur bone mineral density vaules were found to be statistically significantly osteopenic, as compared with obese groups. There was a negative statistical correlation between depression and lomber area bone mineral density. Whereas in femur it was seen that bone mineral density was protected in preobese and obese fibromyalgia patients.The number of studies on this subject is not sufficient. Also the number of patients determined on current studies are low. Further studies, with langer patient numbers and more detailed protocols are needed. (Osteoporoz Dünyasindan 2005; 4: 148-150)Key words: Fibromyalgia, Osteoporosis, Obesity, Depression
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Giris
Fibromiyalji sendromu (FMS), nedeni bilinmeyen, vücudun çesitli yerlerinde agrili noktalarin bulundugu, kronik ve yaygin bir agri sendromudur (1,2). FMSnin osteoporoz için bir risk faktörü olabilecegi öne sürülmüstür. Sedanter yasam tarzi, azalmis fiziksel aktivite ve depresyon, FMSli hastalarda kemik mineral yogunlugunun arastirilmasi fikrini ortaya koymustur (3).Obezite, önemli bir saglik ve fonksiyon bozukluklarina neden olabilen kompleks bir hastaliktir. Obezitede KMY belirgin derecede yüksektir. Yük binen kemiklerde olusan stres nedeniyle trabeküler kemik yogunlugunun arttigi, bunun yani sira yag dokusundaki steroidlerden dolasima geçen östrojenlerin de KMYun korunmasinda rolü oldugu öne sürülmektedir (4). Biz bu çalismada FMSde KMY ve obezitenin FMSli hastalarin KMY üzerine etkisini ortaya koymayi amaçladik.
