In recent years, there has been a dramatic increase in research investigating the epidemiology, diagnosis, prevention, and treatment of osteoporosis and fragility fractures in men. This study was performed to compare the effects of alendronate and calcitonin treatment in male OP osteoporosis. Thirty men with osteoporosis were enrolled in this study. Bone mineral density (BMD) was measured at the proximal femur and lumbar spine by using dual-photon absorptiometry. Thirty men with osteoporosis were randomly divided into two groups. BMD was measured twice as before the treatment and one year later. The end of the treatment a significant improvement was found in the BMD levels of the lomber spine in both groups (p 0.001). There was no significant difference of BMD at the proximal femur when the groups were compared with each other (p0.05). There was no significant difference of BMD levels of proximal femur when the results were compared either within the groups or between two groups (p0.05). Key words: Male osteoporosis, calcitonin, alendronate
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GIRIS
Osteoporoz, kemik kütlesinin azalmasi ve mikromimari yapisinin bozulmasi sonucu kemigin kirilganliginda artis ile karakterize sik rastlanilan bir kemik hastaligidir. Son yillarda erkek osteoporozu ile ilgili yapilan arastirmalarda bir artis göze çarpmaktadir (1-6). Amerika’da yapilan bir çalismada 50 yasin üzerindeki erkeklerde kalça osteoporoz prevalansi % 3-6 arasinda iken, ayni yas grup kadinlarda prevalans %13-18 olarak rapor edilmistir (7). Benzer olarak genis popülasyonla Kanada’da yapilan bir çalismada, 50 yasindan sonraki erkeklerde osteoporoza bagli fraktür sikligi, lomber bölgede %2.9, femur boynunda ise % 4.8 olarak bulunmustur (8). Osteoporoz tedavisinde, kemik rezorpsiyonunu engelleyen ilaçlar ve kemik formasyonunu artiran ilaçlar kullanilmaktadir. Bu ilaçlar tek tek ya da kombine kullanilabilir. Fakat günümüzde tamamen güvenilir, etkili ve genel olarak kabul edilmis bir tedavi henüz tanimlanmamistir (9,10).Erkek osteoporozunun tedavisinde özellikle ikinci jenerasyon bifosfanatlar (alendronat, risedronat) tercih edilmektedir. Bununla birlikte erkek osteoporozunda kalsitonin, androjen veya PTH tedavisi seçenekler arasinda yer almaktadir (11).Bu çalismanin amaci, erkeklerde osteoporoz için kullanilan kalsitonin ve alendronat tedavisinin etkinligini arastirmak ve iki tedavinin etkinligini karsilastirmakti.
