Osteoporosis is common in ankylosing spondylitis (AS), which is a chronic inflammatory rheumatic disease.The aim of this study was to assess the bone loss and the effects of disease activity on bone mineral density in patients with AS.Thirty-three (29 men ,4 women ) patients with AS were included in the study. All of the patients were evaluated as their age, sex, height, weight, history, physical examination, laboratory and AP-lateral thoracic and lumbar vertebrae radiographic findings. Control group was consisted of 35 (31 men 4 women) age and sex-matched healthy person. Mean age and disease duration of the patient group were 43.2 ± 9.9 and 13.18 ± 10.6 years, respectively.Bone mineral density (BMD) was measured by dual energy x-ray absorptiometry (DXA) at lumbar spine and proximal femur regions. BMD did not show statistically significant difference at lumbar region between two groups. However BMD values were 10% lower at femur neck in patient group than controls. The rate of osteopenia and osteoporosis was 42.8 % at the femur neck region in the patient group and 22.8 % in the control group. BMD values at femur neck correlated with age and disease duration.There was no correlation between BMD and BASDAI and BASMI, BASFI, BASGI scores.In conclusion, bone loss is common in AS. Ligament calcification and syndesmophytes may lead to higher BMD values at lumbar region in AS .Thus proximal femur BMD is valuable in the patients with long disease duration. Disease activity has no negative effect on bone density in our study. (Osteoporoz Dünyasindan 2006;12:81-3)Key words: Ankylosing spondylitis, osteoporosis, disease activity
Osteoporosis is common in ankylosing spondylitis (AS), which is a chronic inflammatory rheumatic disease.The aim of this study was to assess the bone loss and the effects of disease activity on bone mineral density in patients with AS.Thirty-three (29 men ,4 women ) patients with AS were included in the study. All of the patients were evaluated as their age, sex, height, weight, history, physical examination, laboratory and AP-lateral thoracic and lumbar vertebrae radiographic findings. Control group was consisted of 35 (31 men 4 women) age and sex-matched healthy person. Mean age and disease duration of the patient group were 43.2 ± 9.9 and 13.18 ± 10.6 years, respectively.Bone mineral density (BMD) was measured by dual energy x-ray absorptiometry (DXA) at lumbar spine and proximal femur regions. BMD did not show statistically significant difference at lumbar region between two groups. However BMD values were 10% lower at femur neck in patient group than controls. The rate of osteopenia and osteoporosis was 42.8 % at the femur neck region in the patient group and 22.8 % in the control group. BMD values at femur neck correlated with age and disease duration.There was no correlation between BMD and BASDAI and BASMI, BASFI, BASGI scores.In conclusion, bone loss is common in AS. Ligament calcification and syndesmophytes may lead to higher BMD values at lumbar region in AS .Thus proximal femur BMD is valuable in the patients with long disease duration. Disease activity has no negative effect on bone density in our study. (Osteoporoz Dünyasindan 2006;12:81-3)Key words: Ankylosing spondylitis, osteoporosis, disease activity
Article in Turkish(Use the link for full-text in Turkish)
Ankilozan spondilit (AS) genç erkeklerde görülen, kronik inflamasyonla karakterize bir hastaliktir. Paravertebral ossifikasyon ve ligamen kalsifikasyonu sebebiyle omurgada ankiloz gelisebilir. Diger inflamatuvar eklem hastaliklarinda oldugu gibi ASde de yaygin osteoporoz (OP) görülme sikligi fazladir (1). ASde kemik kaybi hem omurgada hem de femur boyun bölgesinde hastaligin erken döneminde baslayarak ileri dönemlerinde de devam eder (2). Özellikle ilaçlara ragmen inflamasyonun engellenemedigi ve hastalik süresinin uzun oldugu durumlarda kemik kaybi fazladir (3-5). ASde görülen OP nedenleri arasinda immobilite, kortikosteroid kullanimi, inflamatuvar sitokinlere bagli olarak gelisen kemik metabolizmasindaki bozukluklar, seks steroidlerindeki eksiklik ve eslik eden sessiz bagirsak hastaligi sayilabilir (4,5,6). Bu çalismanin amaci ASde kemik yogunlugunun ölçülerek kontrol grubunun sonuçlari ile karsilastirilmasi ve hastalik aktivitesi ile hastalik süresinin kemik kaybi üzerine olan etkilerinin arastirilmasi idi.
