Tip 2 Diabetes Mellituslu ve Prediyabetli Hastalarda Osteoporoz ve İlişkili Faktörler
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P: 97-103
Ağustos 2022

Tip 2 Diabetes Mellituslu ve Prediyabetli Hastalarda Osteoporoz ve İlişkili Faktörler

Turk J Osteoporos 2022;28(2):97-103
Bilgi mevcut değil.
Bilgi mevcut değil
Alındığı Tarih: 03.03.2021
Kabul Tarihi: 16.07.2021
Yayın Tarihi: 11.08.2022
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ÖZET

Amaç:

Osteoporoz, morbidite ve mortalitenin artmasına neden olan bir hastalıktır. Tedavi edilmemiş hastalarda artmış kırık riski ile ilişkilidir. Osteopeni ve osteoporozun erken teşhisi bu nedenle önemlidir. Diabetes mellitus (DM) artmış iskelet kırıkları ile ilişkilidir. Osteoporoz ve ilişkili kırıklar önemli bir sağlık sorunudur. DM’de osteoporoz sıklığını değerlendirmek için birçok çalışma yapılmış olsa da prediyabet için yalnızca sınırlı veri vardır.

Gereç ve Yöntem:

Kesitsel tipteki bu çalışmaya dahiliye ve endokrinoloji ve metabolizma hastalıkları polikliniğimize başvuran prediyabet hastaları ve tip 2 DM hastaları dahil edildi. Yirmi dokuz kadın ve 6 erkek prediyabet, 53 kadın ve 8 erkek diyabet hastası olarak değerlendirildi. Lomber omurga ve femur kemik mineral yoğunlukları dual-enerji X-ışını absorbsiyometri ile araştırıldı.

Bulgular:

Diyabetik hastaların lomber omurga T-skorları daha düşüktü. Ayrıca majör kırık riski için FRAX değeri daha yüksekti. Prediyabet hastalarının kemik mineral yoğunluğu ölçümleri osteopeni olduğunu gösterdi. Çalışmamızda osteoporoz için majör risk faktörü ileri yaştı.

Sonuç:

Prediyabetik hastalar osteopeni ve osteoporoz açısından risk altındadır.

References

1
World Health Organization (WHO). Diabetes [İnternet]. Available from: URL: https://www.who.int/news-room/factsheets/detail/diabetes. Accessed August 25, 2019.
2
World Health Organization (WHO). Prevelance of diabetes and related factors [İnternet]. Available from: URL: https://www.who.int/diabetes/country-profiles/tur_en.pdf?ua=1. Accessed August 25, 2019.
3
Harvey N, Dennison E, Cooper C. Osteoporosis: impact on health and economics. Nat Rev Rheumatol 2010;6:99-105.
4
Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res 2007;22:465-75.
5
Randell A, Sambrook PN, Nguyen TV, Lapsley H, Jones G, Kelly PJ, et al. Direct clinical and welfare costs of osteoporotic fractures in elderly men and women. Osteoporos Int 1995;5:427-32.
6
Janghorbani M, Van Dam RM, Willett WC, Hu FB. Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture. Am J Epidemiol 2007;166:495-505.
7
Shanbhogue VV, Mitchell DM, Rosen CJ, Bouxsein ML. Type 2 diabetes and the skeleton: new insights into sweet bones. Lancet Diabetes Endocrinol 2016;4:159-73.
8
Hygum K, Starup-Linde J, Harsløf T, Vestergaard P, Langdahl BL. MECHANISMS IN ENDOCRINOLOGY: Diabetes mellitus, a state of low bone turnover-a systematic review and meta-analysis. Eur J Endocrinol 2017;176:137-57.
9
Valderrábano RJ, Linares MI. Diabetes mellitus and bone health: epidemiology, etiology and implications for fracture risk stratification. Clin Diabetes Endocrinol 2018;4:9.
10
Strotmeyer ES, Cauley JA, Schwartz AV, Nevitt MC, Resnick HE, Bauer DC, et al. Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition study. Arch Intern Med 2005;165:1612-7.
11
Xu H, Wang Z, Li X, Fan M, Bao C, Yang R, et al. Osteoporosis and Osteopenia Among Patients With Type 2 Diabetes Aged ≥50: Role of Sex and Clinical Characteristics. J Clin Densitom 2020;23:29-36.
12
Yu EW, Thomas BJ, Brown JK, Finkelstein JS. Simulated increases in body fat and errors in bone mineral density measurements by DXA and QCT. J Bone Miner Res 2012;27:119-24.
13
Napoli N, Chandran M, Pierroz DD, Abrahamsen B, Schwartz AV, Ferrari SL. Mechanisms of diabetes mellitus-induced bone fragility. Nat Rev Endocrinol 2017;13:208-9.
14
Cortet B, Lucas S, Legroux-Gerot I, Penel G, Chauveau C, Paccou J. Bone disorders associated with diabetes mellitus and its treatments. Joint Bone Spine 2019;86:315-20.
15
Holloway-Kew KL, De Abreu LLF, Kotowicz MA, Sajjad MA, Pasco JA. Bone Turnover Markers in Men and Women with Impaired Fasting Glucose and Diabetes. Calcif Tissue Int 2019;104:599-604.
16
Starup-Linde J, Vestergaard P. Biochemical bone turnover markers in diabetes mellitus-A systematic review. Bone 2016;82:69-78.
17
American Diabetes Association. 2. Classification and Diagnosis of Diabetes. Diabetes Care 2017;40:S11-24.
18
Chen L, Magliona DJ, Zimmet PZ. The worldwide epidemiology of type 2 diabetes mellitus-present and future perspectives. Nat Rev Endocrinology 2012;8;228-6.
19
Janghorbani M, Feskanich D, Willet WC, Hu F. Prospective study of diabetes and risk of hip fracture: the Nurses’ Health Study. Diabetes Care 2006;29;1573-8.
20
Bonds DE, Larson JC, Schwartz AV, Strotmeyer ES, Robbins J, Rodriguez BL, et al. Risk of fracture in women with type 2 diabetes: the Women’s Health Initiative Observational Study. J Clin Endocrinol Metab 2006;91:3404-10.
21
Chen C, Chen Q, Nie B, Zhang H, Zhai H, Zhao L, et al. Trends in Bone Mineral Density, Osteoporosis, and Osteopenia Among U.S. Adults With Prediabetes, 2005-2014. Diabetes Care 2020; 43:1008-5.
22
Natour NA, Morin SN, Egeland GM, Weiler HA. Forearm bone density is not elevated in Inuit women with impaired fasting glucose or type 2 diabetes mellitus. Int J Circumpolar Health 2019;78:1-7.
23
Balk EM, Adam GP, Langberg VN, Earley A, Clark P, Ebeling PR, et al. Global dietary calcium intake among adults: a systematic review. Osteoporosis Int 2017;28:3315-4.
24
Nicklas TA, Qu H, Hughes SO, He M, Wagner SE, Foushee HR, et al. Self-perceived lactose intolerance results in lower intakes of calcium and dairy foods and is associated with hypertension and diabetes in adults. Am J Clin Nutr 2011;94:191-8.
25
Im JA, Yu BP, Jeon JY, Kim SH. Relationship between osteocalcin and glucose metabolism in postmenopausal women. Clin Chim Acta 2008;396:66-9.
26
Wongdee K, Charoenphandhu N. Osteoporosis in diabetes mellitus: Possible cellular and molecular mechanisms. World J Diabetes 2011;2:41-8.
27
Anaforoglu I, Nar-Demirer A, Bascil-Tutuncu N, Ertorer ME. Prevalence of osteoporosis and factors affecting bone mineral density among postmenopausal Turkish women with type 2 diabetes. J Diabetes Complications 2009;23:12-7.
28
Brownbill R, Ilich JZ. Lipid profile and bone paradox: higher serum lipids are associated with higher bone mineral density in postmenopausal women. J Womens Health (Larchmt) 2006;15:261-70.
29
Yang Y, Liu G, Zhang Y, Xu G, Yi X, Liang J, et al. Association Between Bone Mineral Density, Bone Turnover Markers, and Serum Cholesterol Levels in Type 2 Diabetes. Front Endocrinol (Lausanne) 2018;9:646.
30
Kotwal A, Drake MT. Our Evolving Understanding of the Relationship Between Diabetes and Bone. Am J Med Sci 2017;354:333-4.
31
Afshinnia F, Chacko S, Zahedi T. Association of lower serum cholesterol levels with higher risk of osteoporosis in type 2 diabetes. Endor Pract 2007;13:620-8.
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