ÖZET
Amaç:
Osteoartritin (OA) patogenezi ve progresyonunun düşük dereceli enflamasyon ile ilişkili olduğu bilinmektedir. Bu çalışmanın amacı öncelikle nötrofil/lenfosit oranı ve platelet/lenfosit oranlarının OA’daki düşük düzey enflamasyonunu belirlemede uygun parametreler olup olmadığını araştırmaktır. İkincil amaç da D vitamini eksikliğinin, OA’nın radyolojik şiddetine ve enflamatuvar parametrelere katkıda bulunup bulunmadığını araştırmaktır.
Gereç ve Yöntem:
Diz ağrısı ile başvuran toplam 623 hasta dosyası incelenerek, çalışmaya dahil edilme kriterlerine uyan, 136 diz osteoartritli hasta dosyası çalışmaya dahil edilmiştir. 25-hidroksivitamin D, tam-kan sayımı, eritrosit sedimentasyon-hızı, C-reaktif protein ve diz radyografilerindeki Kellgren-Lawrance evreleri kayıt edilmiştir.
Bulgular:
Çalışmamıza alınan hastaların %52,2’sinde D vitamini eksikliği saptanmıştır (<20 ng/mL). D vitamini değeri <20 ng/mL ve ≥20 ng/mL olan hastalar arasında ne OA şiddeti ne de enflamasyon parametreleri açısından fark saptanmamıştır. Radyografik osteoartrit hastaların %59,5’inde hafif düzeyde, %40,4’ünde ise orta-şiddetli düzeyde saptanmıştır. Yaş açısından değerlendirildiğinde ise, orta-şiddetli OA olan hastaların yaşı, istatistiksel olarak hafif OA’sı mevcut olan hastalara göre fazla bulunmuştur (p<0,001). Yaş dışındaki parametreler açısından, hafif ve orta-şiddetli OA’sı olan hastalarda fark saptanmamıştır.
Sonuç:
Bu çalışmada, nötrofil/lenfosit oranı ve platelet/lenfosit oranının, diz osteoartritindeki düşük dereceli enflamasyonu belirlemede yetersiz olduğu sonucuna ulaşılmıştır. Ayrıca D vitamini eksikliğinin, radyolojik olarak OA şiddeti ve enflamatuvar parametreler üzerine etkisi saptanmamıştır.
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