Öz
Amaç
Prognostik nutrisyonel indeks (PNI), temel beslenme durumunu değerlendirmek için kullanılan bir indekstir ve osteoporozlu hastaların beslenme durumunu değerlendirmek için kullanılabilir. Ancak PNI’nın osteoporotik kırık için bir gösterge olarak kullanılıp kullanılamayacağı henüz belli değildir. Bu çalışmanın amacı kırılganlık kırığı olan ve olmayan osteoporotik hastalar arasında PNI’da fark olup olmadığını araştırmaktır.
Gereç ve Yöntem
Bu araştırma, osteoporoz tanısı almış 58 kadın hastanın dahil edildiği retrospektif bir çalışmadır. Birinci grupta osteoporotik kırığı olan 28 hasta, ikinci grupta ise kırığı olmayan 30 hasta yer aldı. Birincil sonuç ölçüsü albümin ve lenfosit değerleri kullanılarak hesaplanan PNI idi. İkincil sonuç ölçütleri kemik mineral dansitometrisi (BMD), albümin, lenfosit, kalsiyum, fosfor, alkalen fosfataz, paratiroid hormonu, spot idrarda kalsiyum/kreatin oranı, 25-hidroksi D vitamini değerleri ve FRAX® skorlarıdır.
Bulgular
Ortalama yaş ve vücut kitle indeksi (VKİ) her iki grupta da benzerdi (1. grup: yaş: 67,60±9,78 yıl; VKİ: 27,63±3,89 kg/m2, 2. grup: yaş: 66,83±7,91 yıl; VKİ: 27,04±4,50 kg/m2). Osteoporotik kırığı olan hastalarda FRAX majör osteoporotik kırık riski anlamlı derecede yüksek (p=0,002) ve fosfor düzeyleri daha düşüktü (p=0,002). PNI ve kan albümin düzeylerinde anlamlı bir fark yoktu. Osteoporotik kırığı olan hastalardan vertebra kırığı olanlarda albümin anlamlı olarak daha düşük (p=0,049), vertebral dışı kırığı olanlarda ise düzeltilmiş kalsiyum değeri anlamlı olarak daha düşüktü (p=0,002). Kırılganlık kırığı olan hastalarda PNI, albümin seviyeleri, BMD ve FRAX® arasında herhangi bir korelasyon bulunmadığı görüldü.
Sonuç
Sonuçlarımız osteoporotik hastalarda PNI ile kırılganlık kırıkları arasında bir ilişki bulunmadığını gösterdi.
Anahtar Kelimeler: Anahtar kelimeler: Osteoporoz, osteoporotik kırıklar, prognostik nutrisyonel indeks
Kaynakça
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