Öz
Amaç
Bu çalışmanın amacı, ankilozan spondilit (AS) hastalarında epikardiyal adipoz doku kalınlığı (EATT) ve ilişkili faktörleri incelemek ve elde edilen sonuçları sağlıklı kontrol grubunun bulguları ile karşılaştırmaktır.
Gereç ve Yöntem
Bu kesitsel çalışma, modifiye New York kriterlerine dayanarak AS tanısı almış olan 30 hastayı içermektedir. Kontrol grubu ise 31 sağlıklı gönüllüden oluşmaktadır. Çalışma başlangıcında demografik özellikler kaydedildi. EATT transtorasik ekokardiyografi ile ölçüldü. Bath AS Hastalık Aktivite İndeksi (BASDAI), Bath AS Fonksiyonel İndeksi (BASFI), Bath AS Metroloji İndeksi (BASMI), AS Hastalık Aktivite Skoru (ASDAS), AS Yaşam Kalitesi (ASQoL), Uluslararası Fiziksel Aktivite Anketi Kısa Formu kullanıldı. Fonksiyonel kapasitenin değerlendirilmesi ise altı dakikalık yürüme testi (6-MWT) kullanılarak gerçekleştirildi.
Bulgular
AS grubunda ortalama yaş 41,67±7,56 idi ve bu grupta 21 kişi (%70) erkekti. Ortalama EATT değerleri sırasıyla AS ve kontrol gruplarında 4,40±1,65 mm ve 2,85±1,12 mm idi (p<0,001). EATT ile eritrosit sedimantasyon hızı (ESR) arasında anlamlı bir negatif korelasyon bulundu (p<0,05). EATT ile vücut kitle indeksi (VKİ), BASFI ve BASMI arasında istatistiksel olarak anlamlı pozitif korelasyon mevcuttu. EATT ve sakroileit derecesi arasında lineer bir korelasyon vardı (r=0,400, p=0,028). EATT ile hastalık süresi, C-reaktif protein, kan lipitleri, ASDAS, ASQoL, IPAQ ve 6-MWT arasında anlamlı korelasyon saptanmadı (p>0,05).
Sonuç
Bu çalışmada, EATT değerlerinin AS hastalarında kontrol grubuna göre daha yüksek olduğunu bulunmuştur. EATT ile ilişkili faktörler VKİ, ESR, BASFI, BASMI ve sakroileitin şiddeti olarak belirlendi.
Anahtar Kelimeler: Anahtar kelimeler: Ankilozan spondilit, ateroskleroz, epikardial adipoz doku kalınlığı, vücut kitle indeksi, sakroileit
Kaynakça
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