Öz
Amaç
Osteoporoz (OP), azalmış kemik kütlesi ile karakterize edilen yaygın bir durumdur. Sempatik sinir sistemi, postmenopozal kadınlarda hem kemik yeniden şekillenmesinde hem de vazomotor semptomların gelişiminde rol oynar. Bu çalışma, vazomotor semptomlar yaşayan postmenopozal kadınlarda sempatik deri yanıtı (SDY) ölçümleri kullanılarak, otonomik disfonksiyon ile OP arasındaki ilişkiyi değerlendirmeyi amaçlamaktadır.
Gereç ve Yöntem
Çalışmaya, sıcak basması ve terleme şikayeti olan 45-65 yaş arası toplam 101 postmenopozal kadın dahil edilmiştir. Çalışma, tek merkezli, kesitsel ve gözlemsel bir araştırma olarak tasarlanmıştır. Dual enerji X-ışını absorpsiyometrisi sonuçlarına göre katılımcılar OP, osteopeni ve normal gruplara ayrılmıştır. SDY latans ve amplitüd değerleri ellerden ve ayaklardan bilateral olarak kaydedilmiş ve gruplar arasında karşılaştırılmıştır. Kemik mineral yoğunluğu (KMY) ile SDY sonuçları arasındaki korelasyonlar analiz edilmiştir.
Bulgular
Gruplar arasında SDY latans değerlerinde anlamlı bir fark bulunmamıştır (p>0,05). SDY amplitüdleri OP grubunda en düşük olmasına rağmen, bu fark istatistiksel olarak anlamlı değildir (p>0,05). KMY skorları ile SDY ölçümleri arasında da anlamlı bir korelasyon bulunmamıştır (p>0,05).
Sonuç
Çalışma, postmenopozal kadınlarda SDY yanıtları ile KMY skorları arasında otonomik disfonksiyon göstergesi olabilecek bir ilişki tespit edememiştir.
Anahtar Kelimeler: Anahtar kelimeler: Sempatik deri yanıtı, kemik mineral yoğunluğu, otonomik disfonksiyon, osteoporoz
Kaynakça
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