Abstract

Objective

This study aimed to assess the association between women’s platelet indices and bone mineral density to evaluate osteoporosis, which has a significant impact on quality of life throughout the postmenopausal age.

Materials and Methods

The study was retrospectively designed, and data from 316 postmenopausal patients who applied to the obstetrics and gynecology outpatient clinic between January 2021 and January 2023, underwent bone mineral density measurements during follow-up, and met the inclusion and exclusion criteria were obtained. The data were evaluated in 3 groups as normal, osteopenia, and osteoporosis according to bone mineral density. Platelet indices, age, body mass index (BMI), and bone mineral density were compared with platelet indices in the hemogram results of the patients on the same day.

Results

The mean ages of the osteoporosis, osteopenia, and normal groups were 61.4, 58.4, and 56.2 years, respectively. The mean weight was 72.9 kg in the osteoporosis group, 74.09 kg in the osteopenia group, and 79.4 kg in the normal group. When the groups were compared, no significant difference was observed between age, platelet count, platelet distribution width, mean platelet volume (MPV), platelet-large cell ratio, and thrombocytocrit but a significant difference was found between the osteoporosis and normal groups in terms of BMI (p=0.027).

Conclusion

Although numerous studies in the literature have demonstrated a connection between osteoporosis and MPV and platelet count, our investigation revealed no such association and showed that the risk of osteoporosis decreased as BMI increased.

References

1Rachner TD, Khosla S, Hofbauer LC. Osteoporosis: now and the future. Lancet. 2011;377:1276-87.

2Kanis JA. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. WHO Study Group. Osteoporos Int. 1994;4:368-81.

3Mosekilde L. Age-related changes in vertebral trabecular bone architecture--assessed by a new method. Bone. 1988;9:247-50.

4World Health Organization. Menopause. 2022. Available from:URL:https://www.who.int/news-room/fact-sheets/detail/menopause. Accessed October 17, 2022

5Mundy GR. Osteoporosis and inflammation. Nutr Rev. 2007;65:S147-51.

6Lerner UH. Inflammation-induced bone remodeling in periodontal disease and the influence of post-menopausal osteoporosis. J Dent Res. 2006;85:596-607.

7Siris ES, Adler R, Bilezikian J, Bolognese M, Dawson-Hughes B, Favus MJ, et al. The clinical diagnosis of osteoporosis: a position statement from the National Bone Health Alliance Working Group. Osteoporos Int. 2014;25:1439-43.

8Manolagas SC, Jilka RL. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med. 1995;332:305-11.

9Li XS, Zhang JR, Meng SY, Li Y, Wang RT. Mean platelet volume is negatively associated with bone mineral density in postmenopausal women. J Bone Miner Metab. 2012;30:660-5.

10Akbal A, Gökmen F, Gencer M, Inceer BS, Kömürcü E. Mean platelet volume and platelet distribution width can be related to bone mineralization. Osteoporos Int. 2014;25:2291-5.

11Turgay B, Avşar F. Kemik mineral yoğunluğu ile trombosit endeksleri arasında ilişki var mıdır? JGON. 2021;18:818-21.

12Güzel Y. Postmenopozal Kadınlarda Kemik Mineral Dansitometri Değerleri ile Hematolojik Parametrelerin Karşılaştırılması. Dicle Tıp Dergisi. 2021;48:267-73.

13Yıldırım A, Bulut HT. Association between Bone Mineral Density and Platelet Indices in Postmenopausal Women. Turk J Osteoporos. 2016;22:92-6.

14Kimble RB, Matayoshi AB, Vannice JL, Kung VT, Williams C, Pacifici R. Simultaneous block of interleukin-1 and tumor necrosis factor is required to completely prevent bone loss in the early postovariectomy period. Endocrinology. 1995;136:3054-61.

15Kim HL, Cho HY, Park IY, Choi JM, Kim M, Jang HJ, et al. The positive association between peripheral blood cell counts and bone mineral density in postmenopausal women. Yonsei Med J. 2011;52:739-45.

16Aypak C, Türedi Ö, Bircan MA, Civelek GM, Araz M. Association between mean platelet volume and bone mineral density in postmenopausal women. J Phys Ther Sci. 2016;28:1753-8.

17Salamanna F, Maglio M, Sartori M, Tschon M, Fini M. Platelet Features and Derivatives in Osteoporosis: A Rational and Systematic Review on the Best Evidence. Int J Mol Sci. 2020;21:1762.

18Sürücü GD, Gedik DE. The Relationship Between Laboratory Findings and Bone Mineral Density in Patients with Osteoporosis. Turk J Osteoporos. 2022;28:147-52.

19Lemieux JM, Horowitz MC, Kacena MA. Involvement of integrins alpha(3)beta(1) and alpha(5)beta(1) and glycoprotein IIb in megakaryocyte-induced osteoblast proliferation. J Cell Biochem. 2010;109:927-32.

20Dan K, Gomi S, Inokuchi K, Ogata K, Yamada T, Ohki I, et al. Effects of interleukin-1 and tumor necrosis factor on megakaryocytopoiesis: mechanism of reactive thrombocytosis. Acta Haematol. 1995;93:67-72.

21Unsal E, Aksaray S, Köksal D, Sipit T. Potential role of interleukin 6 in reactive thrombocytosis and acute phase response in pulmonary tuberculosis. Postgrad Med J. 2005;81:604-7.

22Asomaning K, Bertone-Johnson ER, Nasca PC, Hooven F, Pekow PS. The association between body mass index and osteoporosis in patients referred for a bone mineral density examination. J Womens Health (Larchmt). 2006;15:1028-34.

Relationship Between Bone Mineral Density and Platelet Indices in Postmenopausal Period

Abstract

References