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Outcomes of Treatment in Patients with Severe Postmenopausal Osteoporosis: The Effects of Teriparatide Treatment on Bone Mineral Density, Back Pain and Biochemical Parameters
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Original Investigation
VOLUME: 26 ISSUE: 1
P: 6-9
April 2020

Outcomes of Treatment in Patients with Severe Postmenopausal Osteoporosis: The Effects of Teriparatide Treatment on Bone Mineral Density, Back Pain and Biochemical Parameters

Turk J Osteoporos 2020;26(1):6-9
DOI: 10.4274/tod.galenos.2019.92668
Tuba Nazlıgül 1
İlknur Aktaş 2
Feyza Ünlü Özkan 2
Pınar Akpınar 2
1. Sağlık Bilimleri Üniversitesi, Van Eğitim ve Araştırma Hastanesi, Fiziksel Tıp ve Rehabilitasyon Kliniği, Van, Türkiye
2. Sağlık Bilimleri Üniversitesi, Fatih Sultan Mehmet Eğitim ve Araştırma Hastanesi, Fiziksel Tıp ve Rehabilitasyon Kliniği, İstanbul, Türkiye
No information available.
No information available
Received Date: 03.02.2019
Accepted Date: 01.08.2019
Publish Date: 31.03.2020
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ABSTRACT

Objective:

The aim of this study was to determine the effects of teriparatide treatment on bone mineral density (BMD), back pain, and biochemical parameters in patients with severe postmenopausal osteoporosis.

Materials and Methods:

The study included 13 patients with severe postmenopausal osteoporosis who were followed up at our osteoporosis outpatient clinic and completed treatment or currently undergoing treatment with subcutaneous 20 μq/day teriparatide. Patients were retrospectively evaluated before and after treatment with regards to BMD, biochemical parameters, and severity of back pain.

Results:

When the pre and post treatment values of the patients included in the study were compared, there was a statistically significant improvement in the BMD and severity of back pain after treatment (p<0.05), while the biochemical parameters did not differ significantly (p>0.05).

Conclusion:

In patients with severe postmenopausal osteoporosis, teriparatide therapy is seemed to be an effective treatment choice by improving the BMD values and reducing the back pain.

References

1
Rizzoli R. Postmenopausal Osteoporosis: assessment and management. Best Pract Res Clin Endocrinol Metab 2018;32:739-57.
2
Tuzun S, Eskiyurt N, Akarirmak U, Saridogan M, Senocak M, Johansson H, et al. Incidence of hip fracture and prevalence of osteoporosis in Turkey: the FRACTURK study. Osteoporos Int 2012;23:949-55.
3
Yıldızgören MT, Öziş TN, Baki AE, Tutkun E, Yılmaz H, Tiftik T, et al. Evaluation of bone mineral density and 25-hydroxyvitamin D levels in subjects with silica exposure. Environ Health Prev Med 2016;21:149-53.
4
Hodsman AB, Bauer DC, Dempster DW, Dian L, Hanley DA, Harris ST, et al. Parathyroid hormone and teriparatide for the treatment of osteoporosis: A review of the evidence and suggested guidelines for its use. Endocr Rev 2005;26:688-703.
5
Chen P, Miller PD, Rocker R, Resch H, Ranan A, Pavo I, et al. Increase in BMD correlate with improvements in bone microarchitecture with Teriparatide treatment in post-menopausal women with osteoporosis. J Bone Miner Res 2007;22:1173-80.
6
Ma YL, Zeng Q, Donley DW, Ste-Marie LG, Gallagher JC, Dalsky GP, et al. Teriparatide increases bone formation in modeling and remodeling osteons and enhances IGF-II immunoreactivity in postmenopausal women with osteoporosis. J Bone Miner Res 2006;21:855-64.
7
Bodenner D, Redman C, Riggs A. Teriparatide in the management of osteoporosis. Clin Interv Aging 2007;2:499-507.
8
Çevikol A, Karaahmet ÖZ, Gürçay E, Karataş G, Karaca Umay E, Çakcı A. Şiddetli Osteoporozlu Hastalarda Teriparatid Tedavisi: Kemik Mineral Yoğunluğu, Biyokimyasal Parametreler, Sırt Ağrısı ve Yaşam Kalitesi Üzerine Etkiler. Turk J Osteoporos 2014;20:51-5.
9
The WHO Study Group. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Geneva. World Health Organ Tech Rep Ser. 1994;843:1-129.
10
Genant HK, Wu CY, van Kuijk C, Nevitt MC. Vertebral fracture assessment using a semi quantitative technique. J Bone Miner Res 1993;8:1137-48.
11
Akarırmak Ü, Özkul İ. Osteoporoz tedavisinde paratiroid hormon (PTH). Turk J Osteoporos 2002;8:40-6.
12
Rubin MR, Comsan F, Lindsay R, Bilezikian JP. The anabolic effects of parathroid hormone. Osteoporos Int 2002;13:267-77.
13
Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster JY, et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med 2001;344:1434-41.
14
Özşahin M, Büyükkaya R, Kaya E, Baki AE, Aydın Y, Çelebi E, ve ark. Postmenopozal Osteoporoz Tedavisinde Teriparatid ve Alendronat Sodyumun Etkinliğinin Karşılaştırılması. Duzce Medical Journal 2013;15:30-3.
15
Berry SD, Dufour AB, Travison TG, Zhu H, Yehoshua A, Barron R, et al. Changes in bone mineral density (BMD): a longitudinal study of osteoporosis patients in the real-world setting. Arch Osteoporos 2018;12;13:124.
16
Akyol Y, Atmaca A, Durmuş D, Ulus Y, Tander B, Alaylı G. Şiddetli Postmenopozal Osteoporozlu Hastalarda Teriparatid Tedavisinin Ağrı, Yaşam Kalitesi, Depresyon ve Biyokimyasal Parametreler Üzerine Etkisi: Erken Dönem Sonuçlar. Turk J Phys Med Rehab 2011;57:134-8.
17
Orwoll ES, Scheele WH, Paul S, Adami S, Syversen U, Diez-Perez A, et al. The effect of teriparatide [human parathyroid hormone (1-34)] therapy on bone density in men with osteoporosis. J Bone Miner Res 2003;18:9-17.
18
Langdahl BL, Gerald R, Jakop F, Karras D, Ljunggren O, Lems WF, et al. Reduction in fracture rate and back pain and increased quality of life in postmenopausal women treated with teriparatide: 18-month data from the European Forsteo Observational Study (EFOS). Calcif Tissue Int 2009;85:484-93.
19
Nevitt MC, Chen P, Dore RK, Reginster JY, Kiel DP, Zanchetta JR, et al. Reduced risk of back pain following teriparatide treatment:a meta analysis Osteoporos Int 2006;17:273-80.
20
Nakajima A, Shimoji N, Shiomi K, Shimizu S, Moriya H, Einhorn TA, et al. Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34). J Bone Miner Res 2002;17:2038-47.
21
Shi Z, Zhou H, Pan B, Lu L, Liu J, Kang Y, et al. Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis. PLoS One 2016;11:e0168691.