ABSTRACT

Life expectancy in Human Immunodeficieny Virus (HIV) infection patients has increased as a result of highly active antiretroviral treatment, causing a chronic disease process. Treatment agents as well as the longer lasting disease itself seem to bring about new problems. One of these problems is bone loss which was reported to occur frequently in various studies; osteoporosis in 26% and osteopenia in 67% in HIV positive patients. Additional risk factors in these patients were physical inactivity, inadequate nutrition, vitamin D deficiency, low BMI etc. The aim of this case report was to describe clinical findings in three patients we have followed, one with compression fracture and to discuss treatment. (Turkish Journal of Osteoporosis 2012;18:27-30)

Giris

Insan Bagisiklik Yetmezlik Virüsü (Human Immunodeficieny Virus) (HIV) enfeksiyonu olan kisilerde beklenen yasam süreleri, Yüksek Düzeyde Aktif Antiretroviral Tedavilerin (YDAAT) kullanima girmesi ile anlamli düzeyde uzamistir ve artik bu virüsün “ölümcül” bir hastaliktan çok “kronik” bir hastaliga yol açtigi kabul edilmektedir (1,2). Ancak uzayan yasam süreleri, hastaligin kendisinin veya tedavisinde kullanilan ajanlarin neden oldugu, yeni saglik sorunlarini da beraberinde getirmistir. Bu sorunlardan biri de kemik yogunlugunda ortaya çikan kayiplardir. Nitekim yapilmis arastirmalarda HIV pozitif olgularda osteoporoz sikligi %26 (3), osteopeni sikligi ise %67’lere (4) varan oranlarda bildirilmistir.