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Dramatic Response to Ustekinumab Treatment in a Patient with Ankylosing Spondylitis and Crohn’s Disease and Anti-tumor Necrosis Factor-alpha Drug Induced Psoriasis
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Case Report
VOLUME: 26 ISSUE: 3
P: 197-200
December 2020

Dramatic Response to Ustekinumab Treatment in a Patient with Ankylosing Spondylitis and Crohn’s Disease and Anti-tumor Necrosis Factor-alpha Drug Induced Psoriasis

Turk J Osteoporos 2020;26(3):197-200
DOI: 10.4274/tod.galenos.2020.71677
Sevilay Kılıç 1
Hatice Reşorlu 2
Alper Ekinci 1
Ayşe Selcen Bulut Keskin 2
1. Çanakkale Onsekiz Mart Üniversitesi Tıp Fakültesi, Dermatoloji Anabilim Dalı, Çanakkale, Türkiye
2. Çanakkale Onsekiz Mart Üniversitesi Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Çanakkale, Türkiye
No information available.
No information available
Received Date: 24.12.2019
Accepted Date: 16.04.2020
Publish Date: 28.12.2020
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ABSTRACT

Treatment with anti-tumour necrosis factor-alpha (anti-TNF-α) drugs provides significant improvements in many chronic inflammatory diseases with common pathogenesis, including Crohn’s disease, ankylosing spondylitis and psoriasis. However, during these treatments, paradoxically, cutaneous side effects such as psoriasis can be seen. Although its pathophysiology is well understood, it is thought that TNF-α blockade triggers locally excessive interferon-α production in predisposed subjects and causes psoriatic lesions. In this case report, we present a 50-year-old female patient with ankylosing spondylitis and Crohn’s disease who used adalimumab and then infliximab and developed psoriasiform lesions due to these drugs. Anti-TNF-α treatment was discontinued, and ustekinumab was started. Psoriasiform rashes improved; disease activity of ankylosing spondylitis and Crohn’s disease was suppressed. Ustekinumab may be a good option to manage ankylosing spondylitis and patients with Crohn’s disease who develop psoriasiform rashes due to anti-TNF-α drugs.

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